RAF Typhoon jets have operated alongside France's air force in a joint strike targeting an hidden munitions depot in Syria used by the Daesh militant organization, according to the UK's MoD.
The location, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was situated in hills just north of the historic site of Palmyra in Syria's central region.
"Our fighter planes used laser-guided Paveway IV weapons to strike a several approach shafts leading to the site... initial indications indicate the strike was effective," the MoD said.
There was no indication of any civilian impact in the strike conducted Saturday night and each participating jet made a safe return, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - enforced extremist governance over parts of Syria and Iraq until 2019.
"This action demonstrates British leadership, and determination to operate in unison with our partners, to eliminate any resurgence of IS and their violent and radical beliefs in the area," the British Defence Secretary the minister stated.
RAF aircraft have performed surveillance missions over Syria to "deter any attempted comeback" of Islamic State subsequent to its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank the personnel of our armed forces who took part in this operation for their expertise and their courage," Healey added. "Including them were numerous UK service members on duty over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our safety, highlights how our armed forces are ready to step up, all year round, ensuring Britain's security at home and powerful internationally."
Last December, the United States armed forces conducted what it called a "large-scale strike" against Daesh sites in the country, after an ambush resulted in the deaths of two American soldiers and a local interpreter in the Palmyra area.
The United Nations says IS still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.
